Strict Standards: Non-static method AL_HELPER::SetupPaths() should not be called statically in /home/cheaphos/public_html/endo/init.php on line 66

Strict Standards: Non-static method AL_CATEGORY::GetCategoryArray() should not be called statically in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 77

Strict Standards: Non-static method AL_CATEGORY::GetSubCatsArray() should not be called statically in /home/cheaphos/public_html/endo/admin/includes/classes/class.category.php on line 496

Strict Standards: Non-static method AL_CATEGORY::GetSubCatsArray() should not be called statically in /home/cheaphos/public_html/endo/admin/includes/classes/class.category.php on line 496

Strict Standards: Non-static method AL_CATEGORY::GetSubCatsArray() should not be called statically in /home/cheaphos/public_html/endo/admin/includes/classes/class.category.php on line 496

Strict Standards: Non-static method AL_CATEGORY::GetSubCatsArray() should not be called statically in /home/cheaphos/public_html/endo/admin/includes/classes/class.category.php on line 496

Strict Standards: Non-static method AL_CATEGORY::GetSubCatsArray() should not be called statically in /home/cheaphos/public_html/endo/admin/includes/classes/class.category.php on line 496

Strict Standards: Non-static method AL_CATEGORY::GetSubCatsArray() should not be called statically in /home/cheaphos/public_html/endo/admin/includes/classes/class.category.php on line 496

Strict Standards: Non-static method AL_CATEGORY::GetSubCatsArray() should not be called statically in /home/cheaphos/public_html/endo/admin/includes/classes/class.category.php on line 496

Strict Standards: Non-static method AL_CATEGORY::GetSubCatsArray() should not be called statically in /home/cheaphos/public_html/endo/admin/includes/classes/class.category.php on line 496

Strict Standards: Non-static method AL_CATEGORY::GetSubCatsArray() should not be called statically in /home/cheaphos/public_html/endo/admin/includes/classes/class.category.php on line 496

Strict Standards: Non-static method AL_CATEGORY::GetSubCatsArray() should not be called statically in /home/cheaphos/public_html/endo/admin/includes/classes/class.category.php on line 496

Strict Standards: Non-static method AL_CATEGORY::GetSubCatsArray() should not be called statically in /home/cheaphos/public_html/endo/admin/includes/classes/class.category.php on line 496

Strict Standards: Non-static method AL_CATEGORY::GetSubCatsArray() should not be called statically in /home/cheaphos/public_html/endo/admin/includes/classes/class.category.php on line 496

Strict Standards: Non-static method AL_CATEGORY::GetSubCatsArray() should not be called statically in /home/cheaphos/public_html/endo/admin/includes/classes/class.category.php on line 496

Strict Standards: Non-static method AL_CATEGORY::GetSubCatsArray() should not be called statically in /home/cheaphos/public_html/endo/admin/includes/classes/class.category.php on line 496

Strict Standards: Non-static method AL_CATEGORY::GetSubCatsArray() should not be called statically in /home/cheaphos/public_html/endo/admin/includes/classes/class.category.php on line 496

Strict Standards: Non-static method AL_CATEGORY::GetSubCatsArray() should not be called statically in /home/cheaphos/public_html/endo/admin/includes/classes/class.category.php on line 496

Deprecated: Function eregi_replace() is deprecated in /home/cheaphos/public_html/endo/includes/classes/class.categories.php on line 41

Deprecated: Function eregi() is deprecated in /home/cheaphos/public_html/endo/includes/classes/class.article.php on line 269

Deprecated: Non-static method AL_HELPER::ArticleLink() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/includes/classes/class.article.php on line 328

Deprecated: Non-static method AL_HELPER::_MakeArticleURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 435

Deprecated: Non-static method AL_HELPER::_SwapLetters() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 401

Deprecated: Function eregi_replace() is deprecated in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 403

Deprecated: Non-static method AL_HELPER::_MakeArticleURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 435

Deprecated: Non-static method AL_HELPER::_SwapLetters() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 401

Deprecated: Function eregi_replace() is deprecated in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 403

Deprecated: Function eregi() is deprecated in /home/cheaphos/public_html/endo/includes/classes/class.blog.php on line 153

Deprecated: Function eregi() is deprecated in /home/cheaphos/public_html/endo/includes/classes/class.author.php on line 139

Deprecated: Function eregi_replace() is deprecated in /home/cheaphos/public_html/endo/includes/classes/class.article.php on line 999

Deprecated: Function eregi_replace() is deprecated in /home/cheaphos/public_html/endo/includes/classes/class.article.php on line 1000

Deprecated: Function eregi() is deprecated in /home/cheaphos/public_html/endo/includes/classes/class.template.php on line 117

Deprecated: Function ereg_replace() is deprecated in /home/cheaphos/public_html/endo/includes/classes/class.template.php on line 243

Deprecated: Function eregi() is deprecated in /home/cheaphos/public_html/endo/templates/Slick/Panels/PageHeader.php on line 86

Deprecated: Non-static method AL_HELPER::PageLink() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/templates/Slick/Panels/PageHeader.php on line 95

Deprecated: Non-static method AL_HELPER::_MakeURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 498

Deprecated: Function eregi() is deprecated in /home/cheaphos/public_html/endo/templates/Slick/Panels/PageHeader.php on line 86

Deprecated: Non-static method AL_HELPER::PageLink() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/templates/Slick/Panels/PageHeader.php on line 95

Deprecated: Non-static method AL_HELPER::_MakeURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 498

Deprecated: Function eregi() is deprecated in /home/cheaphos/public_html/endo/templates/Slick/Panels/PageHeader.php on line 86

Deprecated: Non-static method AL_HELPER::PageLink() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/templates/Slick/Panels/PageHeader.php on line 95

Deprecated: Non-static method AL_HELPER::_MakeURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 498

Deprecated: Function eregi() is deprecated in /home/cheaphos/public_html/endo/templates/Slick/Panels/PageHeader.php on line 86

Deprecated: Non-static method AL_HELPER::PageLink() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/templates/Slick/Panels/PageHeader.php on line 95

Deprecated: Non-static method AL_HELPER::_MakeURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 498

Deprecated: Function eregi() is deprecated in /home/cheaphos/public_html/endo/templates/Slick/Panels/PageHeader.php on line 86

Deprecated: Non-static method AL_HELPER::PageLink() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/templates/Slick/Panels/PageHeader.php on line 95

Deprecated: Non-static method AL_HELPER::_MakeURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 498

Deprecated: Function eregi() is deprecated in /home/cheaphos/public_html/endo/templates/Slick/Panels/PageHeader.php on line 86

Deprecated: Non-static method AL_HELPER::PageLink() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/templates/Slick/Panels/PageHeader.php on line 95

Deprecated: Non-static method AL_HELPER::_MakeURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 498

Deprecated: Non-static method AL_HELPER::ArticleLink() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/templates/Slick/Panels/ArticleOptionsPanel.php on line 60

Deprecated: Non-static method AL_HELPER::_MakeArticleURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 435

Deprecated: Non-static method AL_HELPER::_SwapLetters() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 401

Deprecated: Function eregi_replace() is deprecated in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 403

Deprecated: Non-static method AL_HELPER::_MakeArticleURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 435

Deprecated: Non-static method AL_HELPER::_SwapLetters() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 401

Deprecated: Function eregi_replace() is deprecated in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 403

Deprecated: Function eregi_replace() is deprecated in /home/cheaphos/public_html/endo/templates/Slick/Panels/ArticleOptionsPanel.php on line 60

Deprecated: Non-static method AL_HELPER::ArticleLink() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/templates/Slick/Panels/ArticleOptionsPanel.php on line 63

Deprecated: Non-static method AL_HELPER::_MakeArticleURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 435

Deprecated: Non-static method AL_HELPER::_SwapLetters() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 401

Deprecated: Function eregi_replace() is deprecated in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 403

Deprecated: Non-static method AL_HELPER::_MakeArticleURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 435

Deprecated: Non-static method AL_HELPER::_SwapLetters() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 401

Deprecated: Function eregi_replace() is deprecated in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 403

Deprecated: Function eregi_replace() is deprecated in /home/cheaphos/public_html/endo/templates/Slick/Panels/ArticleOptionsPanel.php on line 63

Deprecated: Non-static method AL_HELPER::ArticleLink() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/templates/Slick/Panels/ArticleOptionsPanel.php on line 68

Deprecated: Non-static method AL_HELPER::_MakeArticleURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 435

Deprecated: Non-static method AL_HELPER::_SwapLetters() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 401

Deprecated: Function eregi_replace() is deprecated in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 403

Deprecated: Non-static method AL_HELPER::_MakeArticleURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 435

Deprecated: Non-static method AL_HELPER::_SwapLetters() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 401

Deprecated: Function eregi_replace() is deprecated in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 403

Deprecated: Function eregi_replace() is deprecated in /home/cheaphos/public_html/endo/templates/Slick/Panels/ArticleOptionsPanel.php on line 68

Deprecated: Non-static method AL_HELPER::ArticleLink() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/templates/Slick/Panels/ArticleOptionsPanel.php on line 81

Deprecated: Non-static method AL_HELPER::_MakeArticleURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 435

Deprecated: Non-static method AL_HELPER::_SwapLetters() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 401

Deprecated: Function eregi_replace() is deprecated in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 403

Deprecated: Non-static method AL_HELPER::_MakeArticleURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 435

Deprecated: Non-static method AL_HELPER::_SwapLetters() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 401

Deprecated: Function eregi_replace() is deprecated in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 403

Deprecated: Non-static method AL_HELPER::CategoryLink() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/templates/Slick/Panels/RootArticleCategoriesPanel.php on line 77

Deprecated: Non-static method AL_HELPER::_MakeURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 586

Deprecated: Non-static method AL_HELPER::CategoryLink() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/templates/Slick/Panels/RootArticleCategoriesPanel.php on line 77

Deprecated: Non-static method AL_HELPER::_MakeURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 586

Deprecated: Non-static method AL_HELPER::CategoryLink() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/templates/Slick/Panels/RootArticleCategoriesPanel.php on line 77

Deprecated: Non-static method AL_HELPER::_MakeURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 586

Deprecated: Non-static method AL_HELPER::CategoryLink() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/templates/Slick/Panels/RootArticleCategoriesPanel.php on line 77

Deprecated: Non-static method AL_HELPER::_MakeURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 586

Deprecated: Non-static method AL_HELPER::CategoryLink() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/templates/Slick/Panels/RootArticleCategoriesPanel.php on line 77

Deprecated: Non-static method AL_HELPER::_MakeURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 586

Deprecated: Non-static method AL_HELPER::CategoryLink() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/templates/Slick/Panels/RootArticleCategoriesPanel.php on line 77

Deprecated: Non-static method AL_HELPER::_MakeURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 586

Deprecated: Non-static method AL_HELPER::CategoryLink() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/templates/Slick/Panels/RootArticleCategoriesPanel.php on line 77

Deprecated: Non-static method AL_HELPER::_MakeURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 586

Deprecated: Non-static method AL_HELPER::CategoryLink() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/templates/Slick/Panels/RootArticleCategoriesPanel.php on line 77

Deprecated: Non-static method AL_HELPER::_MakeURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 586

Deprecated: Non-static method AL_HELPER::CategoryLink() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/templates/Slick/Panels/RootArticleCategoriesPanel.php on line 77

Deprecated: Non-static method AL_HELPER::_MakeURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 586

Deprecated: Non-static method AL_HELPER::CategoryLink() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/templates/Slick/Panels/RootArticleCategoriesPanel.php on line 77

Deprecated: Non-static method AL_HELPER::_MakeURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 586

Deprecated: Non-static method AL_HELPER::CategoryLink() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/templates/Slick/Panels/RootArticleCategoriesPanel.php on line 77

Deprecated: Non-static method AL_HELPER::_MakeURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 586

Deprecated: Non-static method AL_HELPER::CategoryLink() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/templates/Slick/Panels/RootArticleCategoriesPanel.php on line 77

Deprecated: Non-static method AL_HELPER::_MakeURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 586

Deprecated: Non-static method AL_HELPER::CategoryLink() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/templates/Slick/Panels/RootArticleCategoriesPanel.php on line 77

Deprecated: Non-static method AL_HELPER::_MakeURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 586

Deprecated: Non-static method AL_HELPER::CategoryLink() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/templates/Slick/Panels/RootArticleCategoriesPanel.php on line 77

Deprecated: Non-static method AL_HELPER::_MakeURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 586

Deprecated: Non-static method AL_HELPER::CategoryLink() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/templates/Slick/Panels/RootArticleCategoriesPanel.php on line 77

Deprecated: Non-static method AL_HELPER::_MakeURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 586

Deprecated: Non-static method AL_HELPER::CategoryLink() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/templates/Slick/Panels/RootArticleCategoriesPanel.php on line 77

Deprecated: Non-static method AL_HELPER::_MakeURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 586

Deprecated: Non-static method AL_HELPER::CategoryLink() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/templates/Slick/Panels/ViewArticlePanel.php on line 715

Deprecated: Non-static method AL_HELPER::_MakeURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 586

Deprecated: Non-static method AL_HELPER::AuthorLink() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/includes/classes/class.article.php on line 503

Deprecated: Non-static method AL_HELPER::_MakeURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 467

Deprecated: Non-static method AL_HELPER::GetRelativeDate() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/includes/classes/class.article.php on line 496

Deprecated: Non-static method AL_HELPER::ShortDate() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 264

Deprecated: Non-static method AL_HELPER::GetCategoryListCVS() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/templates/Slick/Panels/ViewArticlePanel.php on line 75

Deprecated: Non-static method AL_HELPER::CategoryLink() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 284

Deprecated: Non-static method AL_HELPER::_MakeURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 586

Deprecated: Non-static method AL_HELPER::GetRatingBar() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/templates/Slick/Panels/ViewArticlePanel.php on line 76

Deprecated: Non-static method AL_HELPER::GetGlossaryTerms() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/includes/classes/class.article.php on line 618

Deprecated: Non-static method AL_HELPER::ArticleLink() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/includes/classes/class.article.php on line 701

Deprecated: Non-static method AL_HELPER::_MakeArticleURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 435

Deprecated: Non-static method AL_HELPER::_SwapLetters() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 401

Deprecated: Function eregi_replace() is deprecated in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 403

Deprecated: Non-static method AL_HELPER::_MakeArticleURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 435

Deprecated: Non-static method AL_HELPER::_SwapLetters() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 401

Deprecated: Function eregi_replace() is deprecated in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 403

Deprecated: Non-static method AL_HELPER::ArticleLink() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/includes/classes/class.article.php on line 708

Deprecated: Non-static method AL_HELPER::_MakeArticleURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 435

Deprecated: Non-static method AL_HELPER::_SwapLetters() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 401

Deprecated: Function eregi_replace() is deprecated in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 403

Deprecated: Non-static method AL_HELPER::_MakeArticleURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 435

Deprecated: Non-static method AL_HELPER::_SwapLetters() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 401

Deprecated: Function eregi_replace() is deprecated in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 403

Deprecated: Non-static method AL_HELPER::ArticleLink() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/includes/classes/class.article.php on line 708

Deprecated: Non-static method AL_HELPER::_MakeArticleURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 435

Deprecated: Non-static method AL_HELPER::_SwapLetters() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 401

Deprecated: Function eregi_replace() is deprecated in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 403

Deprecated: Non-static method AL_HELPER::_MakeArticleURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 435

Deprecated: Non-static method AL_HELPER::_SwapLetters() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 401

Deprecated: Function eregi_replace() is deprecated in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 403

Deprecated: Non-static method AL_HELPER::ArticleLink() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/includes/classes/class.article.php on line 715

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Immunohistochemical localization of cyclooxygenase-2 in radicular cysts
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 »  Home  »  Endodontic Articles 11  »  Immunohistochemical localization of cyclooxygenase-2 in radicular cysts
Immunohistochemical localization of cyclooxygenase-2 in radicular cysts
Results.



In light microscopic examination, all cyst specimens revealed the typical morphology of a radicular cyst. The cyst lumen was partially or entirely lined by nonkeratinized stratified squamous epithelium. The underlying fibrous connective tissue wall was inflamed with variable degrees of inflammatory cell infiltration. Many small blood vessels were scattered within the cystic connective wall, especially concentrated in the regions with an inflammatory infiltrate. The infiltrate consisted mainly of macrophages which were labelled with a- ACT(Fi g.1).
As shown in Fig. 2, COX-2 stain was detected in the lining epithelium and subepithelial fibroblasts, macrophages and endothelial cells in all specimens. COX-2 expression was also noted in the endothelial cells of some small capillaries in the fibrous connective tissue wall with a marked inflammatory cell infiltrate (Fig. 2).No signals were detected in the negative controls of radicular cysts. In addition, COX-2 expression in a gingiva specimen represented with higher levels of inflammation (Fig. 3).
COX-2 expression in radicular cysts with low or high levels of inflammation is listed in Table 1. Differences in COX-2 expression between tissues with low and high levels of inflammation were subsequently analyzed using Fisher’s exact test. A significantly greater COX-2 expression was noted in radicular cysts with high levels of inflammation as compared to the tissues with low levels of inflammatory cell infiltrates (P = 0.0052).

Figure 1. Photograph showing macrophages labelled by a-ACT in both the lining epithelium and underlying inflamed connective tissue wall of a radicular cyst (400x).

DPhotograph showing macrophages labelled by a-ACT in both the lining epithelium and underlying inflamed connective tissue wall of a radicular cyst

Figure 2. Immunolocalization of COX-2 in a radicular cyst. COX-2 stain was detected in the lining epithelium and subepithelial fibroblasts, macrophages and endothelial cells in only one specimen is shown (200x).

Immunolocalization of COX-2 in a radicular cyst. COX-2 stain was detected in the lining epithelium and subepithelial fibroblasts, macrophages and endothelial cells in only one specimen is shown

Figure 3. Inflamed gingival tissues were used as positive control. COX-2 expression was significantly higher in a gingival specimen with higher levels of inflammatory infiltrates (200x).

Inflamed gingival tissues were used as positive control. COX-2 expression was significantly higher in a gingival specimen with higher levels of inflammatory infiltrates

Table 1. The results of COX-2 expression and the grade of inflammation in radicular cysts analyzed in this study.

The results of COX-2 expression and the grade of inflammation in radicular cysts analyzed in this study