Strict Standards: Non-static method AL_HELPER::SetupPaths() should not be called statically in /home/cheaphos/public_html/endo/init.php on line 66

Strict Standards: Non-static method AL_CATEGORY::GetCategoryArray() should not be called statically in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 77

Strict Standards: Non-static method AL_CATEGORY::GetSubCatsArray() should not be called statically in /home/cheaphos/public_html/endo/admin/includes/classes/class.category.php on line 496

Strict Standards: Non-static method AL_CATEGORY::GetSubCatsArray() should not be called statically in /home/cheaphos/public_html/endo/admin/includes/classes/class.category.php on line 496

Strict Standards: Non-static method AL_CATEGORY::GetSubCatsArray() should not be called statically in /home/cheaphos/public_html/endo/admin/includes/classes/class.category.php on line 496

Strict Standards: Non-static method AL_CATEGORY::GetSubCatsArray() should not be called statically in /home/cheaphos/public_html/endo/admin/includes/classes/class.category.php on line 496

Strict Standards: Non-static method AL_CATEGORY::GetSubCatsArray() should not be called statically in /home/cheaphos/public_html/endo/admin/includes/classes/class.category.php on line 496

Strict Standards: Non-static method AL_CATEGORY::GetSubCatsArray() should not be called statically in /home/cheaphos/public_html/endo/admin/includes/classes/class.category.php on line 496

Strict Standards: Non-static method AL_CATEGORY::GetSubCatsArray() should not be called statically in /home/cheaphos/public_html/endo/admin/includes/classes/class.category.php on line 496

Strict Standards: Non-static method AL_CATEGORY::GetSubCatsArray() should not be called statically in /home/cheaphos/public_html/endo/admin/includes/classes/class.category.php on line 496

Strict Standards: Non-static method AL_CATEGORY::GetSubCatsArray() should not be called statically in /home/cheaphos/public_html/endo/admin/includes/classes/class.category.php on line 496

Strict Standards: Non-static method AL_CATEGORY::GetSubCatsArray() should not be called statically in /home/cheaphos/public_html/endo/admin/includes/classes/class.category.php on line 496

Strict Standards: Non-static method AL_CATEGORY::GetSubCatsArray() should not be called statically in /home/cheaphos/public_html/endo/admin/includes/classes/class.category.php on line 496

Strict Standards: Non-static method AL_CATEGORY::GetSubCatsArray() should not be called statically in /home/cheaphos/public_html/endo/admin/includes/classes/class.category.php on line 496

Strict Standards: Non-static method AL_CATEGORY::GetSubCatsArray() should not be called statically in /home/cheaphos/public_html/endo/admin/includes/classes/class.category.php on line 496

Strict Standards: Non-static method AL_CATEGORY::GetSubCatsArray() should not be called statically in /home/cheaphos/public_html/endo/admin/includes/classes/class.category.php on line 496

Strict Standards: Non-static method AL_CATEGORY::GetSubCatsArray() should not be called statically in /home/cheaphos/public_html/endo/admin/includes/classes/class.category.php on line 496

Strict Standards: Non-static method AL_CATEGORY::GetSubCatsArray() should not be called statically in /home/cheaphos/public_html/endo/admin/includes/classes/class.category.php on line 496

Deprecated: Function eregi_replace() is deprecated in /home/cheaphos/public_html/endo/includes/classes/class.categories.php on line 41

Deprecated: Function eregi() is deprecated in /home/cheaphos/public_html/endo/includes/classes/class.article.php on line 269

Deprecated: Non-static method AL_HELPER::ArticleLink() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/includes/classes/class.article.php on line 328

Deprecated: Non-static method AL_HELPER::_MakeArticleURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 435

Deprecated: Non-static method AL_HELPER::_SwapLetters() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 401

Deprecated: Function eregi_replace() is deprecated in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 403

Deprecated: Non-static method AL_HELPER::_MakeArticleURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 435

Deprecated: Non-static method AL_HELPER::_SwapLetters() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 401

Deprecated: Function eregi_replace() is deprecated in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 403

Deprecated: Function eregi() is deprecated in /home/cheaphos/public_html/endo/includes/classes/class.blog.php on line 153

Deprecated: Function eregi() is deprecated in /home/cheaphos/public_html/endo/includes/classes/class.author.php on line 139

Deprecated: Function eregi_replace() is deprecated in /home/cheaphos/public_html/endo/includes/classes/class.article.php on line 999

Deprecated: Function eregi_replace() is deprecated in /home/cheaphos/public_html/endo/includes/classes/class.article.php on line 1000

Deprecated: Function eregi() is deprecated in /home/cheaphos/public_html/endo/includes/classes/class.template.php on line 117

Deprecated: Function ereg_replace() is deprecated in /home/cheaphos/public_html/endo/includes/classes/class.template.php on line 243

Deprecated: Function eregi() is deprecated in /home/cheaphos/public_html/endo/templates/Slick/Panels/PageHeader.php on line 86

Deprecated: Non-static method AL_HELPER::PageLink() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/templates/Slick/Panels/PageHeader.php on line 95

Deprecated: Non-static method AL_HELPER::_MakeURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 498

Deprecated: Function eregi() is deprecated in /home/cheaphos/public_html/endo/templates/Slick/Panels/PageHeader.php on line 86

Deprecated: Non-static method AL_HELPER::PageLink() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/templates/Slick/Panels/PageHeader.php on line 95

Deprecated: Non-static method AL_HELPER::_MakeURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 498

Deprecated: Function eregi() is deprecated in /home/cheaphos/public_html/endo/templates/Slick/Panels/PageHeader.php on line 86

Deprecated: Non-static method AL_HELPER::PageLink() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/templates/Slick/Panels/PageHeader.php on line 95

Deprecated: Non-static method AL_HELPER::_MakeURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 498

Deprecated: Function eregi() is deprecated in /home/cheaphos/public_html/endo/templates/Slick/Panels/PageHeader.php on line 86

Deprecated: Non-static method AL_HELPER::PageLink() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/templates/Slick/Panels/PageHeader.php on line 95

Deprecated: Non-static method AL_HELPER::_MakeURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 498

Deprecated: Function eregi() is deprecated in /home/cheaphos/public_html/endo/templates/Slick/Panels/PageHeader.php on line 86

Deprecated: Non-static method AL_HELPER::PageLink() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/templates/Slick/Panels/PageHeader.php on line 95

Deprecated: Non-static method AL_HELPER::_MakeURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 498

Deprecated: Function eregi() is deprecated in /home/cheaphos/public_html/endo/templates/Slick/Panels/PageHeader.php on line 86

Deprecated: Non-static method AL_HELPER::PageLink() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/templates/Slick/Panels/PageHeader.php on line 95

Deprecated: Non-static method AL_HELPER::_MakeURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 498

Deprecated: Non-static method AL_HELPER::ArticleLink() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/templates/Slick/Panels/ArticleOptionsPanel.php on line 60

Deprecated: Non-static method AL_HELPER::_MakeArticleURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 435

Deprecated: Non-static method AL_HELPER::_SwapLetters() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 401

Deprecated: Function eregi_replace() is deprecated in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 403

Deprecated: Non-static method AL_HELPER::_MakeArticleURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 435

Deprecated: Non-static method AL_HELPER::_SwapLetters() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 401

Deprecated: Function eregi_replace() is deprecated in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 403

Deprecated: Function eregi_replace() is deprecated in /home/cheaphos/public_html/endo/templates/Slick/Panels/ArticleOptionsPanel.php on line 60

Deprecated: Non-static method AL_HELPER::ArticleLink() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/templates/Slick/Panels/ArticleOptionsPanel.php on line 63

Deprecated: Non-static method AL_HELPER::_MakeArticleURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 435

Deprecated: Non-static method AL_HELPER::_SwapLetters() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 401

Deprecated: Function eregi_replace() is deprecated in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 403

Deprecated: Non-static method AL_HELPER::_MakeArticleURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 435

Deprecated: Non-static method AL_HELPER::_SwapLetters() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 401

Deprecated: Function eregi_replace() is deprecated in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 403

Deprecated: Function eregi_replace() is deprecated in /home/cheaphos/public_html/endo/templates/Slick/Panels/ArticleOptionsPanel.php on line 63

Deprecated: Non-static method AL_HELPER::ArticleLink() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/templates/Slick/Panels/ArticleOptionsPanel.php on line 68

Deprecated: Non-static method AL_HELPER::_MakeArticleURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 435

Deprecated: Non-static method AL_HELPER::_SwapLetters() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 401

Deprecated: Function eregi_replace() is deprecated in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 403

Deprecated: Non-static method AL_HELPER::_MakeArticleURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 435

Deprecated: Non-static method AL_HELPER::_SwapLetters() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 401

Deprecated: Function eregi_replace() is deprecated in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 403

Deprecated: Function eregi_replace() is deprecated in /home/cheaphos/public_html/endo/templates/Slick/Panels/ArticleOptionsPanel.php on line 68

Deprecated: Non-static method AL_HELPER::ArticleLink() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/templates/Slick/Panels/ArticleOptionsPanel.php on line 81

Deprecated: Non-static method AL_HELPER::_MakeArticleURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 435

Deprecated: Non-static method AL_HELPER::_SwapLetters() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 401

Deprecated: Function eregi_replace() is deprecated in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 403

Deprecated: Non-static method AL_HELPER::_MakeArticleURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 435

Deprecated: Non-static method AL_HELPER::_SwapLetters() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 401

Deprecated: Function eregi_replace() is deprecated in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 403

Deprecated: Non-static method AL_HELPER::CategoryLink() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/templates/Slick/Panels/RootArticleCategoriesPanel.php on line 77

Deprecated: Non-static method AL_HELPER::_MakeURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 586

Deprecated: Non-static method AL_HELPER::CategoryLink() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/templates/Slick/Panels/RootArticleCategoriesPanel.php on line 77

Deprecated: Non-static method AL_HELPER::_MakeURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 586

Deprecated: Non-static method AL_HELPER::CategoryLink() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/templates/Slick/Panels/RootArticleCategoriesPanel.php on line 77

Deprecated: Non-static method AL_HELPER::_MakeURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 586

Deprecated: Non-static method AL_HELPER::CategoryLink() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/templates/Slick/Panels/RootArticleCategoriesPanel.php on line 77

Deprecated: Non-static method AL_HELPER::_MakeURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 586

Deprecated: Non-static method AL_HELPER::CategoryLink() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/templates/Slick/Panels/RootArticleCategoriesPanel.php on line 77

Deprecated: Non-static method AL_HELPER::_MakeURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 586

Deprecated: Non-static method AL_HELPER::CategoryLink() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/templates/Slick/Panels/RootArticleCategoriesPanel.php on line 77

Deprecated: Non-static method AL_HELPER::_MakeURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 586

Deprecated: Non-static method AL_HELPER::CategoryLink() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/templates/Slick/Panels/RootArticleCategoriesPanel.php on line 77

Deprecated: Non-static method AL_HELPER::_MakeURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 586

Deprecated: Non-static method AL_HELPER::CategoryLink() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/templates/Slick/Panels/RootArticleCategoriesPanel.php on line 77

Deprecated: Non-static method AL_HELPER::_MakeURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 586

Deprecated: Non-static method AL_HELPER::CategoryLink() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/templates/Slick/Panels/RootArticleCategoriesPanel.php on line 77

Deprecated: Non-static method AL_HELPER::_MakeURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 586

Deprecated: Non-static method AL_HELPER::CategoryLink() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/templates/Slick/Panels/RootArticleCategoriesPanel.php on line 77

Deprecated: Non-static method AL_HELPER::_MakeURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 586

Deprecated: Non-static method AL_HELPER::CategoryLink() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/templates/Slick/Panels/RootArticleCategoriesPanel.php on line 77

Deprecated: Non-static method AL_HELPER::_MakeURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 586

Deprecated: Non-static method AL_HELPER::CategoryLink() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/templates/Slick/Panels/RootArticleCategoriesPanel.php on line 77

Deprecated: Non-static method AL_HELPER::_MakeURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 586

Deprecated: Non-static method AL_HELPER::CategoryLink() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/templates/Slick/Panels/RootArticleCategoriesPanel.php on line 77

Deprecated: Non-static method AL_HELPER::_MakeURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 586

Deprecated: Non-static method AL_HELPER::CategoryLink() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/templates/Slick/Panels/RootArticleCategoriesPanel.php on line 77

Deprecated: Non-static method AL_HELPER::_MakeURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 586

Deprecated: Non-static method AL_HELPER::CategoryLink() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/templates/Slick/Panels/RootArticleCategoriesPanel.php on line 77

Deprecated: Non-static method AL_HELPER::_MakeURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 586

Deprecated: Non-static method AL_HELPER::CategoryLink() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/templates/Slick/Panels/RootArticleCategoriesPanel.php on line 77

Deprecated: Non-static method AL_HELPER::_MakeURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 586

Deprecated: Non-static method AL_HELPER::CategoryLink() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/templates/Slick/Panels/ViewArticlePanel.php on line 715

Deprecated: Non-static method AL_HELPER::_MakeURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 586

Deprecated: Non-static method AL_HELPER::AuthorLink() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/includes/classes/class.article.php on line 503

Deprecated: Non-static method AL_HELPER::_MakeURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 467

Deprecated: Non-static method AL_HELPER::GetRelativeDate() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/includes/classes/class.article.php on line 496

Deprecated: Non-static method AL_HELPER::ShortDate() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 264

Deprecated: Non-static method AL_HELPER::GetCategoryListCVS() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/templates/Slick/Panels/ViewArticlePanel.php on line 75

Deprecated: Non-static method AL_HELPER::CategoryLink() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 284

Deprecated: Non-static method AL_HELPER::_MakeURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 586

Deprecated: Non-static method AL_HELPER::GetRatingBar() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/templates/Slick/Panels/ViewArticlePanel.php on line 76

Deprecated: Non-static method AL_HELPER::GetGlossaryTerms() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/includes/classes/class.article.php on line 618

Deprecated: Non-static method AL_HELPER::ArticleLink() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/includes/classes/class.article.php on line 701

Deprecated: Non-static method AL_HELPER::_MakeArticleURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 435

Deprecated: Non-static method AL_HELPER::_SwapLetters() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 401

Deprecated: Function eregi_replace() is deprecated in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 403

Deprecated: Non-static method AL_HELPER::_MakeArticleURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 435

Deprecated: Non-static method AL_HELPER::_SwapLetters() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 401

Deprecated: Function eregi_replace() is deprecated in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 403

Deprecated: Non-static method AL_HELPER::ArticleLink() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/includes/classes/class.article.php on line 708

Deprecated: Non-static method AL_HELPER::_MakeArticleURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 435

Deprecated: Non-static method AL_HELPER::_SwapLetters() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 401

Deprecated: Function eregi_replace() is deprecated in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 403

Deprecated: Non-static method AL_HELPER::_MakeArticleURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 435

Deprecated: Non-static method AL_HELPER::_SwapLetters() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 401

Deprecated: Function eregi_replace() is deprecated in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 403

Deprecated: Non-static method AL_HELPER::ArticleLink() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/includes/classes/class.article.php on line 708

Deprecated: Non-static method AL_HELPER::_MakeArticleURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 435

Deprecated: Non-static method AL_HELPER::_SwapLetters() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 401

Deprecated: Function eregi_replace() is deprecated in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 403

Deprecated: Non-static method AL_HELPER::_MakeArticleURLSafe() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 435

Deprecated: Non-static method AL_HELPER::_SwapLetters() should not be called statically, assuming $this from incompatible context in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 401

Deprecated: Function eregi_replace() is deprecated in /home/cheaphos/public_html/endo/admin/includes/classes/class.helper.php on line 403

Deprecated: Function eregi_replace() is deprecated in /home/cheaphos/public_html/endo/templates/Slick/Panels/ViewArticlePanel.php on line 352

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Invasion of vascular cells in vitro by Porphyromonas endodontalis
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 »  Home  »  Endodontic Articles 5  »  Invasion of vascular cells in vitro by Porphyromonas endodontalis
Invasion of vascular cells in vitro by Porphyromonas endodontalis
Discussion - References.



Discussion.
Microorganisms from oral focal infections may disseminate throughout the body and subsequently colonize extraoral tissues. During septicaemia, microorganisms from the oral cavity may attach to and invade sites along the arterial tree. This theory was originally formulated to address the putative association between periodontal disease and cardiovascular disease. The theory could also apply to microorganisms associated with endodontic infections due to bacteraemia after endodontic therapy (Debelian et al . 1995, Debelian et al . 1998). The interactions between the bacteria and the vascular cells could initiate, or more likely, exacerbate the inflammatory lesion of atherosclerosis (Ross 1999).
In contrast to the focal infection theory, microorganisms from endodontic infections may not be seeding distant sites in the body, but rather the dental pulp may be infected by a general bacteraemia (Drancourt et al . 1998, Aboudharam et al. 2000). Therefore, bacteria found in the dental pulp could be a reflection of microorganisms found systemically. These bacteria may be indicators of pathogens causing morbidity at extraoral sites. More specifically, invasive bacteria in the dental pulp may be indicative of bacteria causing disease at the endothelium.

Figure 3. Invasion of human coronary artery endothelial cells by clinical isolates. Bacteria were isolated from infected root canals and tested using the antibiotic protection assay. Error bars represent the standard deviation (n = 3).

Invasion of human coronary artery endothelial cells by clinical isolates

The invasion ability of strains of P. endodontalis in this study was heterogeneous. Of the three strains tested, only P. endodontalis ATCC 35406 was invasive. This finding was not unexpected, since previous studies have demonstrated that the invasion abilities of both P. gingivalis and P. intermedia vary amongst the different strains (Dorn et al. 1998). Conversely, certain strains of P. loeschii, P. nigrescens, and P. tannerae that were not tested in this study may be invasive. The different strains of BPBs from the oral cavity vary in their ability to invade nonphagocytic cells. The intracellular location of P. endodontalis was different from that of P. gingivalis. Although both are invasive, the two microorganisms have evolved different mechanisms of controlling their intracellular environment in order to survive (Hackstadt 2000).
In summary, we have demonstrated that some, but not all, microorganisms associated with endodontic infections can invade human coronary artery endothelial cells (HCAEC) and coronary artery smooth muscle cells (CASMC). A next step would involve animal models to determine whether the bacteraemic conditions would produce the same effect in vivo. If the hypothesis regarding atherosclerotic exacerbations caused by the direct interactions between oral bacteria and vascular cells is correct, then microorganisms in the pulp chamber may represent a source of infectious organisms that contribute to the pathogenesis of CHD.

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