D. Tziafas, O. Pantelidou, A. Alvanou, G. Belibasakis & S. Papadimitriou
Departments of Endodontology, School of Dentistry, Histology and Embryology, Faculty of Medicine,
Clinical Sciences/Surgery Clinic, School of Veterinary Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.
The objective of the present experiment was to study the early pulpal cell response and the onset of reparative dentine formation after capping application of MTA in mechanically exposed pulps.
The present experiments indicate that MTA is an effective pulp-capping material, able to stimulate hard tissue bridge formation during the early wound healing process. The stereotypic pulp defence mechanism by which primitive matrix (fibrodentine) trigger expression of the odontoblastic potential of pulpal cells seems to be related to the dentinogenic activity of MTA. Further experimental data are needed to determine whether interactions between extracellular matrix components (including fibronectin) and endogenous signaling molecules (growth factors) take place after pulp capping with MTA.